Keating Lab

Evolution and engineering of protein-protein interactions

Elaboration of the Homer1 Recognition Landscape Reveals Incomplete Divergence of Paralogous EVH1 Domains

Computational methods for the structure-based design of protein-binding peptides

Exploring the Activation Landscape of Pro-Apoptotic BAK Through the Discovery of Human BH3-Only and Non-Native Peptide Binders

Modeling and designing Bcl-2 family protein interactions using high-throughput interaction data

Design of selective peptide inhibitors of anti-apoptotic Bfl-1 using experimental screening, structure-based design, and data-driven modeling

Determinants of protein-peptide interaction specificity in the Bcl-2 and TRAF families

Modular design of coiled coils to target bZIP transcription factors

Computational design of orthogonal antiparallel homodimeric coiled coils

Design of Protein-Protein Interaction Specificity Using Computational Methods and Experimental Library Screening

How sequence determines function in bacterial two-component signaling protein

Determining Protein Interaction Specificity of Native and Designed bZIP Family Transcription Factors

Investigation of coiled-coil interactions between proteins of the spindle pole body

Flexibility and specificity of the interaction of MCL-1 with BIM BH3

Computational prediction of coiled-coil interaction structure specificity

Modeling the flexibility of alpha helices in protein interfaces: structure based design and prediction of helix-mediated protein-protein interactions

Computational approaches for the design and prediction of protein-protein interactions

Redesigning specificity in miniproteins